IL4 and helminthiasis: Furthermore, our results revealed that Adrb2−/− mice infected with C. sinensis showed significantly lower production of type 2 cytokines, in particular, IL-4 (Figure 3D, P<0.001) and IL-13 (Figure 3E, P<0.01), compared to that observance in Adrb2+/+ mice with worm infection.