The expectation is that upregulated genes in response to IL27 treatment will be positively co-expressed with IL27. As expected, upregulated genes in response to IL27 treatment were positively co-expressed with IL27 in both human prostate cancer (GSE32448; FDR = 0.014, NES = 1.47; Figure 4D) and human melanoma cancer (TCGA-SKCM; FDR = 0.000, NES = 3.33; Figure 4E), further supporting IL27 as a driver gene. The gene discussed is IL27; the disease is prostate cancer.