HLA-DRB1 and rheumatoid arthritis: In HLA-DRB1*04-positive subjects, on the other hand, the minor allele (T) of rs74058715 was associated with a significantly reduced risk of anti-CCP-positive RA after adjustment for age, sex, smoking status, PTPN22 R620W, and number of HLA-DRB1*04 alleles (p=0.01; Table 3).