When compared with control patients in their first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycle attempt without PRP or G-CSF treatment, no statistically significant difference regarding implantation, clinical pregnancy and miscarriage rates was found between the two groups, suggesting the combined use of intrauterine PRP and subcutaneous G-CSF a potential new strategy for endometrial receptivity improvement (33). This evidence concerns the gene CSF3 and Miscarriage.