ADAM10 expression was significantly increased in compensated CHF rats (1.47 ± 0.21; P = NS) but decreased in decompensated animals (0.79 ± 0.03; P < 0.01), as compared with sham-operated rats (1.0 ± 0.03) (Figure 5H). The gene discussed is ADAM10; the disease is congestive heart failure.