Considering that corin plays a beneficial role against the development of either dilated cardiomyopathy (DCM) or reduced ejection fraction, HF, and regulation of salt homeostasis (Tripathi et al., 2019), upregulation of cardiac corin in compensated CHF rats may play a role in maintaining normal Na+ balance, whereas the decline in this key enzyme in decompensated subgroup likely aggravates salt retention, edema formation, and cardiac hypertrophy. Here, CORIN is linked to cardiac hypertrophy.