PCSK6 and congestive heart failure: In line with these changes, PCSK6 abundance was significantly increased in the compensated subgroup (1.5 ± 0.18; P < 0.05), but reduced in decompensated animals (0.74 ± 0.09; P < 0.05), as compared with sham-operated rats (1.0 ± 0.04) (Figure 5C), whereas the expression of PCSK6 was increased in both compensated and decompensated CHF rats (1.52 ± 0.17; P < 0.05 and 1.28 ± 0.23; P = NS, respectively), when compared with the control group (1.0 ± 0.04) (Figure 5G).