CORIN and hydrops fetalis: Although some studies have found that cardiac corin undergoes downregulation in HF, other studies reported opposite findings (Langenickel et al., 2004; Tran et al., 2004; Jiang et al., 2005; Calderone et al., 2006; Chen et al., 2010; Gladysheva et al., 2013; Ichiki et al., 2013).