For instance, a mutated PA83 variant unable to bind to its native receptors due to mutations in the receptor-binding domain (termed mPA83), was fused to EGF (epidermal growth factor) and thus redirected to EGF receptors (EGFR), which are highly expressed in many cancer cells (Mechaly et al., 2012; Zahaf et al., 2017). Here, EGF is linked to cancer.