Previous studies had reported that MARCH1 can regulate diverse signaling pathways, such as Wnt/β-catenin, PI3K/AKT/β-catenin, and PTEN/AKT pathways to control cancer development (Meng et al., 2016; Xie et al., 2019b; Dai et al., 2020). The gene discussed is MARCHF1; the disease is cancer.