Furthermore, studies in our lab found that MARCH1 was overexpressed in liver cancer (Xie et al., 2019a), and downregulation of MARCH1 induced by drugs such as secalonic acid-F and resveratrol could suppress HCC development (Xie et al., 2019b; Dai et al., 2020). Here, MARCHF1 is linked to hepatocellular carcinoma.