NaV1.1 loss-of-function mutations responsible for Dravet Syndrome impact inhibitory neurons more severely than their excitatory counterparts, and these cells fail during periods of sustained activity (Yu et al., 2006; Tai et al., 2014). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.