By 9 months of age, these mice recapitulate many pathological changes seen in tauopathies: tangle-like tau inclusions in their brain, neuronal and synaptic loss, atrophy of dendrites, changes in electrophysiological properties of pyramidal neurons, and signs of cognitive and motoric impairments (Ramsden et al., 2005; SantaCruz et al., 2005; Rocher et al., 2010; Crimins et al., 2012; Kopeikina et al., 2013a,b; Scott et al., 2016; Holton et al., 2020; Kubota and Kirino, 2021). This evidence concerns the gene MAPT and tauopathy.