Thus, the biological significance of this increase alone may be small; however, it is in line with previous suggestions on tau-mediated hyperexcitability of neurons in mutant mice (Roberson et al., 2007; Ittner et al., 2010; Devos et al., 2013; Holth et al., 2013) and in humans with tauopathy (Amatniek et al., 2006; Vossel et al., 2013). Here, MAPT is linked to tauopathy.