We then inferred the ability of a tumour to evade the immune response via downregulation of target genes by examining the binding of neuroblastoma CRC transcription factors (MYCN, ASCL1, HAND2,ISL1, PHOX2B, GATA3 and TBX2; Extended Data Fig. 4a) to the parent gene locus of the prioritized antigens4. Here, PHOX2B is linked to neuroblastoma.