Consistent with a report demonstrating Htra3 as an inhibitor of TGF-ß signaling (a tumor suppressor in human hematologic malignancies) [28], we also found that overexpression of Htra3 in 32D murine myeloid cells significantly inhibited TGF-ß-induced apoptosis (Fig. 4i). This evidence concerns the gene HTRA3 and hematologic disorder.