TP53 and acute myeloid leukemia: Moreover, we observed AML (erythroid leukemia) development in the group transplanted with ITD/ITD lin− cells overexpressing Htra3 5 months after transplantation (one of five mice, cut off: 1st of August 2021), and the combined knockdown of Lin28a and overexpression of Htra3 in ITD/ITD cells induced AML (two of three mice) with a much shorter latency of one month and a similar morphology as leukemic cells obtained from ITD/ITD; p53 KO double-transgenic mice.