Although the biallelic loss of TP53 is a rare event in AML, the TP53 tumor suppressor gene is frequently inactivated in tumors through a two-hit mechanism, in which one allele carries a missense mutation and the other allele is lost by the deletion of human chromosome 17p, which may give rise to the complete loss of wt-p53 function. Here, TP53 is linked to acute myeloid leukemia.