Interestingly, 90% of ITD/ITD; p53−/− and 52% of ITD/ITD; p53+/− mice with acute leukemia demonstrated biclonal disease, with the coexistence of AML and ALL/lymphoma (e.g., #1348: Fig. 2a–d; #1352: Supplementary Fig. 5), while this phenomenon was observed only in one ITD/ITD mouse. The gene discussed is TP53; the disease is acute leukemia.