Animals with only AML in the ITD/ITD; p53+/− group showed a significant increase in common myeloid progenitors (CMPs) compared with that in ITD/ITD mice with CMML, p53+/− and WT mice (Fig. 3a, b, Supplementary Fig. S9e), while granulocyte-monocyte progenitors (GMPs) in the ITD/ITD; p53+/− group were not increased compared with that in the ITD/ITD-alone group or WT mice (Supplementary Fig. S9f). Here, TP53 is linked to acute myeloid leukemia.