The incidence of AML was further significantly increased in ITD/ITD; p53−/− mice (83%) (Supplementary Figs. 5 and 6), while most p53−/− mice developed lymphoma/lymphoblastic leukemia (87%) and none of the p53−/− mice developed AML (Supplementary Fig. 7) as reported previously [18]. This evidence concerns the gene TP53 and acute lymphoblastic leukemia.