HIF1A and infection: As shown in Fig. 5, infection with Mtb-AG significantly upregulated the expression of inflammatory molecules, such as S100A8, S100A9, S100A12, CRP, HIF1A, MMP1, MMP9, TBX21, and activated NK cell marker, KLRG, surface receptors, PPARG, CD14, as well as Th-2 type markers, IL4 and ARG1 (Fig. 5).