The association of GIGYF1 pLOF with T2D replicated in GHS but we did not replicate associations for TNRC6B and PFAS. There are differences between these two cohorts; UKBB is a population-based cohort with T2D diagnoses obtained from inpatient records while GHS is a health system-based cohort and includes both inpatient and outpatient diagnoses. This evidence concerns the gene PFAS and type 2 diabetes mellitus.