CST3 and urinary system disorder: Notably, GIGYF1 pLOF also associated with increased levels of the kidney injury biomarker cystatin c (p = 6.65 × 10–6, effect = 0.36 SD) and increased diagnosis of urinary system disorders (p = 7.32 × 10–5, OR = 2.71) (Tables 4 and 5).