Most of these genes are already known to be causal for T2D including GCK, HNF1A, SLC30A8, IRS2 and HNF4A. Given that there is a common variant association with T2D at TNRC6B but conflicting results for TNRC6B pLOF in UKBB and GHS, further study of this locus may be warranted. Here, GCK is linked to type 2 diabetes mellitus.