IRS2 and type 2 diabetes mellitus: Most of these genes are already known to be causal for T2D including GCK, HNF1A, SLC30A8, IRS2 and HNF4A. Given that there is a common variant association with T2D at TNRC6B but conflicting results for TNRC6B pLOF in UKBB and GHS, further study of this locus may be warranted.