Interestingly, we found a cluster of five Alu elements, AluY (297 bp), AluSx1 (301 bp), AluYb8 (318 bp), AluSx1 (307 bp), and AluSx1 (276 bp), at Chr. 3: 49,353,360–49,355,409 near GPX1, exhibiting hypermethylation and loss of methylation entropy in breast cancer (Fig. 5c and Table S3). Here, GPX1 is linked to breast carcinoma.