Herein, we observed an increase in bleomycin induced TGFβ1 and the type I receptor at day 5 after bleomycin in the Ppp1r15a gene deficient animals, however we did not observe an exacerbation of TGFβ induced effects in the fibroblast CRISPR model suggesting that any TGFβ receptor-associated mechanisms are fibroblast-independent in lung fibrosis. Here, TGFB1 is linked to pulmonary fibrosis.