MYC and neoplasm: By partitioning cells into groups having consistent patterns of CNVs, we observed that Vκ*MYC tumours are comprised of 4–8 malignant cell subpopulations with distinct CNV profiles (Fig. 3a and Supplementary Fig. 3a, b), underscoring the power of scRNA-seq to delineate malignant subpopulations not detected by bulk approaches.