EIF2AK4 and neoplasm: Notably, a similar set of terms related to ISR-GCN2 was also detected using non-negative matrix factorization (Supplementary Fig. 6d), as were a separate set of terms related to proliferative processes akin to Similarity Program B described above (Supplementary Fig. 6e), further supporting the existence of these subclonal malignant programs in Vκ*MYC tumours.