Indeed, recent work has hypothesized cytoplasmic RBM20 may be similar to the cytoplasmic RNP granules associated with neurodegeneration24, such as TAU for Alzheimer’s disease, Huntingtin for Huntington’ disease, and FUS for amyotrophic lateral sclerosis (ALS)56,57. Here, RBM20 is linked to early-onset autosomal dominant Alzheimer disease.