Indeed, recent work has hypothesized cytoplasmic RBM20 may be similar to the cytoplasmic RNP granules associated with neurodegeneration24, such as TAU for Alzheimer’s disease, Huntingtin for Huntington’ disease, and FUS for amyotrophic lateral sclerosis (ALS)56,57. This evidence concerns the gene HTT and amyotrophic lateral sclerosis.