In senescent cells, fragments of chromatin are shuttled to the cytoplasm, via nuclear membrane blebbing,34 and are recognized by cGAS.30,31,35 We and others reported that cytoplasmic chromatin activates the cGAS-STING pathway, stimulating the pro-inflammatory responses of senescence.30,31,35 In addition to senescence, cytoplasmic chromatin is observed in cancer, aging, and other stressed conditions, leading to cGAS activation.36,37 We therefore hypothesized that cytoplasmic chromatin upon SARS-CoV-2 infection activates cGAS. The gene discussed is CGAS; the disease is cancer.