More importantly, combined NRasG12D and EZH2-deficiency significantly and progressively enhanced the expansion of myeloid cell compartments, resulting in accumulation of myeloid progenitors, immature myeloid cells and megakaryocytes, but decreased lymphoid and erythroid cells, illustrating that the oncogenic cooperation between NRasG12D and EZH2-deficiency manifested a more profound impact on hematopoietic differentiation to drive leukemia progression. The gene discussed is EZH2; the disease is leukemia.