EZH2 and leukemia: Together, by single-cell transcriptomic profiling of HSPCs at distinct stages of leukemia development, we found that oncogenic NRasG12D and/or EZH2-deficiency preserved the overall structure of hematopoietic differentiation trajectories similar to HSPCs in healthy BMs; however, more genes displayed altered expression during advanced stages of leukemia progression especially in EZH2-deficient HSPCs.