GEM and leukemia: To determine whether and how EZH2/PRC2 regulates Gem expression, we first surveyed EZH2-catalyzed H3K27me3 at the Gem locus but did not observe any enrichment of H3K27me3 ChIP-seq signals in various hematopoietic and leukemia cell types, suggesting that EZH2 may not directly regulate Gem transcription through epigenetic mechanisms.