In addition, chemokines were relatively higher expressed in immune cells (e.g., CCL4, and CXCL2), while the type 5 ductal cells commonly expressed high levels of the corresponding receptors, indicating that these chemokines served as critical players in regulating diverse types of immune cells infiltration in PDAC tumor microenvironment (Fig. 6E). The gene discussed is CXCL2; the disease is neoplasm.