TSPAN8 and cancer: In particular, these cell lineages were as follows: (1) the Cancer stem cells characterized with high ALDH1A1 [8] and NES [9] expression; (2) the Ductal cells specifically expressing cell markers MMP7, TSPAN8, SOX9, and LCN2; [10, 11] (3) the Monocyte highly expressing BASP1 [12] and TNF; [13] (4) the T cells with high expression of CD3D [14] and CD27; [15] (5) the Macrophage specifically express the markers HLA − DRB5 and NUPR1; [16] (6) the NK cells expressing KLRC1 [17] and TMIGD2 [12].