In cardiac and liver tissues, as shown in Fig. 2A−D and Supplementary Fig. S2A−S2D, the levels of phospho-Ser2448-mTOR, phospho-Thr389-S6K, and phospho-Thr37/46–4EBP1 were decreased in the F and FH groups compared to the Con group, and the decreases were more pronounced in the FH group than in the H group. The gene discussed is EIF4EBP1; the disease is familial hyperaldosteronism.