PARP1 and leukemia: However, according to some conflicting results, since acetylation inhibits DNA repair factors, and hypomethylation is in favor of hyperacetylation, a combination of a hypomethylation agent with PARP inhibitors can induce apoptosis in human leukemia and lymphoma cells through acetylation of Ku70, Ku80, PARP1, ERCC1, and XPF [160].