To date, most studies that aimed to predict the therapeutic response to ICB treatments have focused on the intrinsic properties of tumor cells, including tumor mutational burden (TMB) [4] and microsatellite instability (MSI)/mismatch repair (MMR) status [5] and properties reflecting the immune phenotype, such as PD-L1 expression [6] and immune cell infiltration [7]. Here, CD274 is linked to neoplasm.