Interestingly, we observed that multiple driver genes, including lysine methyltransferase 2D (KMT2D), TP53, AT-rich interaction domain 1A (ARID1A), and NOTCH1, tended to show a higher prevalence (Fig. 5c–e, p < 0.2) in the HLA-B HED low subgroup versus the high subpopulation. This evidence concerns the gene KMT2D and hypohidrotic ectodermal dysplasia.