The SLC45A3–FGFR2 fusion contains most of the promoter region of SLC45A3 and only the non-coding region of exon 1, which has the similar oncogenic mechanism to the most famous TMPRSS2–ERG fusion gene existing in more than 50% of prostate cancers [45, 46]. The gene discussed is SLC45A3; the disease is Familial prostate cancer.