Prorenin associated negatively with the first-trimester trajectory of uPVV in Model 2 (i.e., adjusted for gestational age, CL number, maternal age, BMI, parity, smoking status, fetal gender and the diagnosis of polycystic ovary syndrome), while the aldosterone/renin ratio associated positively with the first-trimester trajectory of PV in both Model 1 (adjusted for gestational age only) and Model 2. The gene discussed is REN; the disease is polycystic ovary syndrome.