The result of the study showed a statistically significant difference between the mean relative expression of MMP2 and MMP9 in the healing vs non-healing group, and hence, the null hypothesis (that there is no correlation between baseline MMPs 1, 2, 7, 9 expressions in periapical granuloma and periapical wound healing after surgical endodontic treatment) was rejected. This evidence concerns the gene MMP2 and periapical granuloma.