ACHE and myasthenia gravis: Unlike AChR antibody-associated MG (AChR-MG), MuSK-MG displays different clinical profile including prominent involvement of bulbar and cranial muscles and rapid progression with myasthenic crisis at an earlier stage of disease course and shows a limited response to conventional treatments such as acetylcholinesterase inhibitors (ACEI), intravenous immunoglobulin (IVIg) and thymectomy [4, 5].