In summary, our findings identified that lncRNA SNHG1 regulated by SP1 play a promoting role in osteoporosis development that suppressing osteogenic differentiation and angiogenesis but facilitating osteoclast differentiation by modulating SFRP1-mediated Wnt signaling through sponging miR-181c-5p. The gene discussed is SFRP1; the disease is osteoporosis.