TNFRSF10B and neoplasm: Along with factors regulating the varying expression of DR5 (Ashkenazi, 2015), apoptotic regulators (Spencer et al., 2009), or negatively charged sialylated O-linked glycans within DR5 (Wagner et al., 2007), heterogenous tumor cells may also exploit the described mechanism of differential negative charge distribution across the selective membrane domains to interfere with receptor clustering, the apoptotic threshold, and clinical resistance.