Based on our mechanistic work, it is possible that mGlu1 PAMs will have broad utility in other disorders where I/E balance is perturbed such as epilepsy, autism, and Alzheimer’s disease (Busche and Konnerth, 2016; Fritschy, 2008; Gao and Penzes, 2015). The gene discussed is GRM1; the disease is early-onset autosomal dominant Alzheimer disease.