The 3xTgAD mouse model for Alzheimer’s disease-like pathology (Oddo et al., 2003) shows phospho-tau accumulation in post-synaptic targets of the EC, namely hippocampus and basolateral amygdala, as well as electrophysiological signatures indicating increased EC neuronal excitability (Mandino et al., 2020). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.