We used a triple-transgenic mouse model for Alzheimer’s disease (3xTgAD) (Oddo et al., 2003) in which the presence of phospho-tau (a precursor for the hallmark tauopathy of neurofibrillary tangles) early in development (Mastrangelo and Bowers, 2008; Yeh et al., 2011) leads to EC damage. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.