MAPT and Alzheimer disease: The 3xTgAD mouse model for Alzheimer’s disease-like pathology (Oddo et al., 2003) shows phospho-tau accumulation in post-synaptic targets of the EC, namely hippocampus and basolateral amygdala, as well as electrophysiological signatures indicating increased EC neuronal excitability (Mandino et al., 2020).