A previous study showed that pSS patients who are anti-Ro/SSA positive, or double positive for both anti-Ro/SSA and anti-La/SSB, present a higher SGUS score than negative patients [24], and we have also reported that being double positive for anti-Ro/SSA and anti-La/SSB is positively associated with SGUS severity [21]. The gene discussed is SSB; the disease is peeling skin syndrome.