In light of findings of a HERVW envelope protein detected in leukocytes of patients with COVID-19 (12), the presence of syncytium in infected lung tissue (49), and the fusogenic properties of HERV-derived synctin-1 and syncytin-2 (33–35), we present data that might support the presence of HERVW envelope transcription in response to infection. The gene discussed is ERVFRD-1; the disease is COVID-19.