In addition to the core target IL6 (red), there were five secondary targets (pink), including TNF, CXCL8, MAPK8, MAPK3, and CASP3, and six tertiary targets (seashell), including IL1B, CCL2, MAPK1, ICAM1, MAPK14, and RELA, as well as seven quaternary targets (seashell), including STAT1, NOS3, SERPINE1, IL1A, BAX, BCL2, and PRKCA, indicating that the effect of LHQW on the prevention and control of COVID-19 was closely related to the regulation of various targets (Supplementary Figure 3). Here, SERPINE1 is linked to COVID-19.