We built 30 models as a function of the different adipocytokines (i.e., adiponectin, leptin and Ad/L ratio), of the different MetS components (i.e., abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low HDL), and according to whether only nuisance predictors were included (i.e., main effects and two-way interactions derived from the interaction between adipocytokines, HOMA-IR, and MetS component) or whether they also contained the predictor of interest (i.e., the interaction between adipocytokines, HOMA-IR, and MetS component). Here, LEP is linked to metabolic syndrome.