INSR and early-onset autosomal dominant Alzheimer disease: Alternatively, the undesirable effect of triglycerides on the positive association between the Ad/L ratio and cognition could be due to their ability to penetrate the blood-brain barrier (BBB) and induce central leptin and insulin receptor resistance [48], two phenomena increasingly associated with ageing-related cognitive decline and Alzheimer’s disease (AD) [10, 49, 50].