Finally, as it has been shown that clamp removal or angiotensin II inhibition can reverse the changes in blood pressure in 2K1C animals (26) and that angiotensin converting enzyme (ACE) inhibition can revert angiotensin II-induced SIRT1 downregulation (44), ACE inhibitors/angiotensin receptor blockers are likely able to restore SIRT1 levels in renovascular hypertension. This evidence concerns the gene ACE and renovascular hypertension.