In addition to being associated with prognosis after curative resection among patients with ICC, we found that G12 KRAS variants but not non-G12 KRAS variants were associated with lymphatic metastasis, especially G12V KRAS variants, which were enriched in patients with lymphatic metastasis (9 [6.3%] vs 16 [1.8%]; P = .005) (eTable 5 in the Supplement). The gene discussed is KRAS; the disease is intrahepatic cholangiocarcinoma.