,16,17 The Macular atrophy in Pro re Nata versus Treat-and-Extend (MANEX) study reported that the incidence of new atrophy lesion in consecutive naïve treated nAMD eyes receiving VEGF inhibitors was approximately 19% and 22% at 2 and 3 years of treatment, respectively.9 This evidence concerns the gene VEGFA and Atrophy.