CAD and Stormorken syndrome: Deletion of the CC1 domain (mCh-ctSTIM1-ΔCC1) restored ctSTIM1 activity to the level seen with CAD, as did the introduction of R304W, a naturally occurring mutation that causes Stormorken syndrome by constitutively activating STIM1 (Misceo et al., 2014; Morin et al., 2014; Nesin et al., 2014; Figure 6—figure supplement 1).