ITIH4 and infection: Based upon data from 21 of the Env-IMCs, we determined the impact of several characteristics of virus-infected cells on ADCC AUC, including the degree of target cell infection (percentage of p24+ cells), proportion of CD4 downregulated p24+ cells, and level of gp120 shedding (evaluated by the percentage of A32 binding to CD4+ p24− cells), using pairwise correlation.