SOCS5 and colorectal cancer: 2016). In addition, the targeting of sirtuin 2 (SIRT2) by miR-212-5p is important because it inhibits the metastasis and proliferation of colorectal cancer cells (Du et al. 2020). The same inhibitory effect on proliferation was also found in HepG2 hepatocellular carcinoma cells by downregulating suppressor of cytokine signaling 5 (SOCS5) (Han et al. 2020).