2015; Wang & Dong 2019). Recent studies have revealed that in addition to metabolic regulation, these enzymes also play a vital role in signaling, proliferation, and the designation of cancer stem cell (CSC) tumor phenotypes. Multifaceted regulation of PEPCK, FBPase, and G6Pase through transcription, epigenetics, post-translational modification, and enzymatic activity can be observed in different cancers (Leithner et al. 2015; Montal et al. 2015). The gene discussed is PCK2; the disease is cancer.