Repeating analyses using robust mendelian randomisation approaches for both univariable and multivariable mendelian randomisation led to generally consistent associations between apoB and risk of disease in first-degree relatives (appendix 1 tables S11–15, appendix 2 pp 3–6), with risk of type 2 diabetes in DIAMANTE (appendix 1 table S16, appendix 2 p 7), and with lifespan (appendix 1 table S9). Here, APOB is linked to type 2 diabetes mellitus.