PCSK9 and diabetes mellitus: In-vitro and mendelian randomisation analyses have shown that increased activity of the LDL pathway related to proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency is associated with an increased incidence of diabetes.36–38,40–43 The finding that the incidence of dysglycaemia was higher in individuals with cholesterol-depleted apoB particles and lower in individuals with cholesterol-enriched apoB particles is also consistent with our hypothesis.