APOB and heart disorder: In univariable mendelian randomisation, a higher risk of heart disease was evident in all first-degree relatives of individuals with genetically elevated apoB (fathers: OR 1·20, 95% CI 1·16–1·25, FDR-adjusted p=1·9 × 10−21; mothers: 1·14, 1·09–1·19, FDR-adjusted p=5·4 × 10−9; siblings: 1·27, 1·20–1·35, FDR-adjusted p=7·6 × 10–16).