We assessed the rigour of these findings using multivariable mendelian randomisation by including genetic instruments for other major atherogenic lipoprotein lipids (LDL cholesterol and triglycerides), and comparing findings to previously published results.10,12 Finally, we sought replication of our findings for lifespan and type 2 diabetes using findings from large-scale genome-wide association study (GWAS) consortia, given that multivariable analyses using parental data showed evidence of an effect of apoB on these outcomes in the current study. Here, APOB is linked to type 2 diabetes mellitus.