APOB and type 2 diabetes mellitus: In multivariable mendelian randomisation, the direction of effect was reversed: higher apoB was associated with elevated risk of type 2 diabetes (mothers: 1·34, 1·06–1·70, FDR-adjusted p=0·041), although the increase in risk was weaker in fathers (1·17; 0·94–1·46, FDR-adjusted p=0·24; figure 1B).