The reasons for choosing MELTF-AS1 for further research are as follows: (1) the abundance of MELT-AS1 in these deregulated lncRNAs is relatively high; (2) the expression level of MELTF-AS1 is related to the prognosis of patients with osteosarcoma; and (3) the role of MELTF-AS1 in osteosarcoma has not been reported before. This evidence concerns the gene VEPH1 and osteosarcoma.