In addition to Arhgap24, Srgap1, and the other GTPase-activating proteins, other genes involving small GTPase-mediated pathways (Table 2) may also mediate miR-145-5p-induced podocyte injury (e.g., PLCE1, which mutations have been shown to cause podocyte injury and kidney diseases).39 The gene discussed is PLCE1; the disease is kidney disorder.