Previous studies on primary non-metastatic and metastatic colorectal cancer stem-like cells (CR-CSLCs) have found that INPP4B is expressed at low levels in non-metastatic CR-CSLCs and at high levels in metastatic CR-CSLCs, plays a tumour suppressor role in non-metastatic CR-CSLCs cells and plays an oncogenic role in metastatic CR-CSLCs, depending on different molecular mechanisms 4. Here, INPP4B is linked to neoplasm.