Compared to high-moderate differentiation, TNM early stage (I-II) and small tumour size (<6 cm), the IRS of INPP4B was significantly decreased in low-undifferentiated and TNM advanced stage (III-IV, Figure 1E, 1F), while the IRS of INPP4B was slightly decreased in large tumour size (≥6 cm, Figure 1G), not reaching statistical significance. This evidence concerns the gene IARS1 and neoplasm.