To explore the possible mechanism by which INPP4B promotes GC cell progression, we used WB to detect the changes in some important downstream proteins of INPP4B, such as p-SGK3(Thr320), SGK3, p-Akt(Ser473) and AKT, in AGS-overexpressing and BGC-823-knockdown cell lines. Here, SGK3 is linked to gastric cancer.