Ng et al reported that the level of circulating miR-1246 at 2-hour after portal vein reperfusion positively correlated with serum AST and ALT levels in HCC recipients after LT and in vitro experiments found the injury-induced activation and differentiation of macrophages significantly elevated the expression and secretion of miR-1246 25. The gene discussed is GPT; the disease is hepatocellular carcinoma.