Furthermore, miR-375 transfection (Fig. 4A) resulted in significant ERBB2 downregulation compared to the mock transfection, while miR-375 inhibitor transfection restored the expression of ERBB2 compared to the inhibitor mock transfection in ESCC cell lines, KYSE-70, KYSE-180, and EAC cell line FLO-1, but not in JHU-ad1 (Fig. 4B). Here, ERBB2 is linked to esophageal squamous cell carcinoma.