NLK and colorectal carcinoma: More specifically, we addressed the relationships among XIST, miR-92b-3p, and NLK in CRC first by investigating the expressions of XIST and miR-92b-3p in the CRC and normal colorectal tissues, and by analyzing the effect of the XIST/miRNA-92b-3p/NLK signaling axis on the carcinomagenesis and progression of CRC, using a dual luciferase reporter system and by silencing XIST and miR-92b-3p.