uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers 4, including prostate cancer 34-36, bladder cancer 37, 38, colon cancer 39, breast cancer 40, 41, melanoma 42, brain cancer 43, lung cancer 44, renal cell carcinoma 45, liver cancer 46, 47, gastric cancer 48, 49, ovarian cancer 50, 51, head and neck cancer 52, cervical cancer 53 and pancreatic cancer 54. The gene discussed is PLAUR; the disease is Familial prostate cancer.