PIK3CA and cancer: Mechanistically, inhibition of uPAR with siRNA or uncoupling of uPAR from integrin-linked tyrosine receptors (IL-TKRs) will inhibit the PI3K/AKT/mTOR/HIF1α signaling pathway, resulting in impaired glucose uptake and a reduction of pyruvate kinase-2 (PKM2) and other glycolytic enzymes, thereby controlling the metabolism of cancer cells 6.