MAPK8 and neoplasm: In human AGS gastric cancer cells, uPAR can be stimulated by prostaglandin E2 via the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, Src/EGFR/JNK1/2, and Erk1/2/NF-κB signaling pathways, thereby promoting tumor metastasis 119.