Moreover, CKS2 methylation levels in the tumor tissues in LUAD, head and neck squamous cell carcinoma, bladder urothelial carcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma, prostate adenocarcinoma, and uterine corpus endometrial carcinoma were significantly lower than those in the adjacent normal tissues (Figure 5A). This evidence concerns the gene CKS2 and bladder transitional cell carcinoma.